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In bodybuilding, Nolvadex (Tamoxifen Citrate) is used as both an anabolic steroid cycle ancillary drug and as recovery or as a post anabolic steroid cycle therapy drug. It is an anabolic steroid with strong androgenic properties. As with any anabolic steroid, the dose is dependent on several factors such as the individual body weight and body composition, and the total dose of the drug.[11]
One study has shown that Nolvadex increases fat mass via both direct hypertrophy and via an increase in water retention.[12]
Nolvadex is well tolerated by bodybuilders on a macrobiotic diet.
4.2. Blood Flow
Nolvadex (Tamoxifen Citrate) is a synthetic drug which inhibits catecholamines, which increases blood flow
4.3. Skeletal Muscle
Supplementation of Tamoxifen Citrate (20-50mg/kg) increased muscle mass in lean and hyperinsulinemic individuals, but not in hyperinsulinemic or obese individuals.[13] The increase was independent of the other anti-oxidant effects, despite an increasing effect on lipogenesis and an increase on the formation of myogenic differentiation factors.[13]
4.4. Insulin Sensitivity
In persons with hypovolaemic and hyperinsulinemic syndrome (HIS), it is known that tamoxifen (a thiazolidinediones derivative) is an insulin sensitive substance.[5] These individuals were also able to synthesize thiazolidinediones from thiamine in order to reduce the rate of secretion of insulin from the bloodstream,[14] which can be achieved either via glucuronidation, either via synthesis of a thiazolidinediones derivative,[15] or both.[15]
Nolvadex (Tamoxifen Citrate) is an anabolic steroid that facilitates the synthesis of thiazolidinediones, a thiazolidinedione derivative known as thiamine.[17][18][19] Tamoxifen (in particular the 5-methylthiazolidinedione form) is associated with higher rates of hepatic glucose production, and may have an antiatherogenic effect in a similar fashion to caffeine.[20]
Nolvadex (Tamoxifen Citrate) may play a role in both metabolic disease (inflammation, or aging) and in metabolic syndrome, such that there is potential for it to act as an anti-aging agent. However, it is uncertain whether it will exert any anti-aging properties, and more research is
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